miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis

miRNA-26b Overexpression in Ulcerative Colitis-associated Carcinogenesis

BACKGROUND Longstanding ulcerative colitis (UC) bears a high risk for development of UC-associated colorectal carcinoma (UCC). The inflammatory microenvironment influences microRNA expression, which in turn deregulates target gene expression. microRNA-26b (miR-26b) was shown to be instrumental in normal tissue growth and differentiation. Thus, we aimed to investigate the impact of miR-26b in in...

Carcinogenesis in Ulcerative Colitis

Pulmonary function in ulcerative colitis

 Abstract Background: Pulmonary involvement in ulcerative colitis (UC) is thought to be rare. There is not a definite document about the question that "Is the lung a target organ in inflammatory bowel disease?" The aim of the present study is to compare lung function between cases with UC and healthy controls. This study will also be of interest about searching the outbreak of pulmonary functio...

Ibadronate may prevent colorectal carcinogenesis in mice with ulcerative colitis.

An increased incidence of colorectal carcinoma is known to occur in patients with ulcerative colitis, which displays a cycle of recurrence-remission in the colorectal mucosa. Repeated oral doses of 3% dextran sulfate sodium subsequent to a single intraperitoneal injection of azoxymethane induces chronic ulcerative colitis, resulting in an increased incidence of high-grade dysplasia and submucos...

Nephritis Associated with Ulcerative Colitis

Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colon and rectum, characterized by mucosal inflammation and typically presenting with bloody diarrhea. Crohn’s disease is characterized by transmural inflammation of the gut wall and can affect any part of the tubular gastrointestinal tract. Although the underlying etiology and exact pathogenesis remain fully unclarifi...